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KMID : 0362220120390040339
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Journal of The Korean Research Society for Dental Materials
2012 Volume.39 No. 4 p.339 ~ p.340
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Characteristics and Biocompatibility of Three-Dimensional (3D) Polycaprolactone (PCL) Scaffold Coated with Plasma-Polymerized Acrylic Acid (PPAAc) and Hydroxyapatite (HAp) Film
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Lee Sang-June
Seo Ki-Won
Ko Yeong-Mu
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Abstract
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In this study, we have prepared hydroxyapatite (HAp) coated three-dimensional (3D) polycaprolactone (PCL) scaffolds by plasma polymerization and biomimetic method, and then evaluated the biological behavior of MC3T3-E1 on the 3D PCL scaffolds surface coated with plasma-polymerized acrylic acid (PPAAc) thin film and HAp film. PPAAc thin film formed on the 3D PCL scaffolds was examined by contact angle measurement and fourier transform infrared spectroscopy. The results of surface characterization showed that PPAAc thin film indicated the hydrophilic surface property and contained the carboxyl groups. Nano-size crystals of HAp were uniformly coated on the modified 3D PCL scaffolds surface through the ionic interaction between the calcium ions and the carboxyl groups of PPAAc thin film. In vitro cell tests revealed that the surface modification of 3D PCL scaffolds with HAp nanocrystal improved the growth of the osteoblastic MC3T3-E1 cells and didn’t affect the cell differentiation.
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KEYWORD
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Hydroxyapatite, Plasma polymerization, Polycaprolactone, Three-dimensional scaffolds
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